OREANDA-NEWS. April 11, 2016. Novel Single-Story Aeon™ 950 MHz at University of Leeds: the world’s first compact, single-story 950 MHz NMR magnet for high-resolution protein NMR is being introduced at ENC 2016.  It also integrates advanced refrigeration technology, and obviates the need for any cryogen refills.  This new single-story 950 MHz magnet has been successfully installed at the University of Leeds, UK.  Previous 950 MHz magnets required specialized two-story NMR laboratories.

For the Astbury Centre for Structural Molecular Biology at University of Leeds, the single-story Aeon 950 MHz magnet could be installed without building adaptations.  It incorporates a novel CryoProbe™ now for both 13C and 15N direct detection. This compact ultra-high field magnet and probe technology enables the determinination of structures, dynamics and interactions of globular proteins, as well as the study of advanced functional and disease mechanisms of intrinsically disordered proteins.
 
Dr. Alex Breeze, Professor of Biomolecular NMR at the University of Leeds, stated: “We are tremendously excited by our new Aeon 950 MHz instrument, which will be complemented with cutting-edge cryo-electron microscopy and other structural biology techniques.  In particular, the combination of 950 MHz field strength and the novel direct-detection capabilities of the latest CryoProbes allow us to access critical structural and dynamic information on important biological systems and medically relevant targets with optimum sensitivity and resolution.  Indeed, we have already obtained impressive 1H-15N TROSY data on unlabelled proteins at natural isotopic abundance expressed in mammalian cells on our new 950 MHz system.”