OREANDA-NEWS. February 17, 2016. Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”) announces it was notified on February 13, 2016, that Susan Kilsby, Chairman of the Company, acquired 1,600 American Depositary Shares (“ADSs”) at an average price of \\$158.4134 per ADS. The transaction took place “over the counter”.

One ADS is equal to three Ordinary Shares of 5 pence each in the Company.

This notification is to satisfy the Company’s obligations under 3.1.4(R)(1)(a) of the Disclosure Rules and Transparency Rules.

NOTES TO EDITORS

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty medicines to meet significant unmet patient needs.

We focus on providing treatments in Rare Diseases, Neuroscience, Gastrointestinal and Internal Medicine and we are developing treatments for symptomatic conditions treated by specialist physicians in other targeted therapeutic areas, such as Ophthalmics.

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