OREANDA-NEWS. December 22, 2015. Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”) announces that Ordinary Shares (“Shares”) and American Depositary Shares (“ADSs”) of the Company, as set out below, have been acquired today for the Non-Executive Directors, being the part of their total fees that are paid in shares for the period of service from October 1 to December 31, 2015.

Type of Security (1)

Number of Shares/ADSs

Dominic Blakemore

Shares

137

Olivier Bohuon

Shares

163

William Burns

Shares

156

Dr. Steven Gillis

ADSs

53

Dr. David Ginsburg

ADSs

49

David Kappler

Shares

144

Susan Kilsby

ADSs

155

Sara Mathew

ADSs

60

Anne Minto

Shares

158

(1) One ADS is equal to three Shares.

The Shares and ADSs were acquired on the London Stock Exchange and NASDAQ respectively at ?44.567 per Share and \\$198.0411 per ADS.

This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a) of the Disclosure Rules and Transparency Rules.

In addition, for the purposes of the EU Transparency Directive, it is noted that the Company’s Home Member State is the United Kingdom.

Oliver Strawbridge
Senior Assistant Company Secretary

For further information please contact:

NOTES TO EDITORS

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty medicines to meet significant unmet patient needs.

We focus on providing treatments in Rare Diseases, Neuroscience, Gastrointestinal and Internal Medicine and we are developing treatments for symptomatic conditions treated by specialist physicians in other targeted therapeutic areas, such as Ophthalmics.