OREANDA-NEWS A new method of vaccination without injections was created by scientists of SSU, Smorodintsev Influenza Research Institute and SPbPU as part of an international research team. According to the authors of the development, the introduction of the vaccine is carried out through the hair follicles without damaging the skin. The results of the study, supported by a grant from the Russian Science Foundation (RGNF), are published in the Journal of Materials Chemistry in.

Vaccination is one of the main strategies for the prevention of infectious diseases. Traditional vaccines are administered intramuscularly or subcutaneously with needles, which is a painful procedure that violates the integrity of the skin, experts of the N.G. Chernyshevsky SSU said. As the SSU experts explained, there is currently a tendency to replace such approaches with non-injectable ones. Particular emphasis is placed on the development of methods of percutaneous immunization, since the skin contains a large number of innate immunity cells, the activation of which is a prerequisite for the development of a strong adaptive immune response.

"The introduction of the vaccine into the skin can be done, for example, with the help of microneedles. This is a less painful and more effective method compared to conventional needles. However, our team has set the task to find a vaccination method that allows to completely avoid physical damage to the skin," said Yulia Svenskaya, one of the authors of the study, senior researcher at the Laboratory of Remotely Controlled Systems for Theranostics at the Scientific Medical Center of Saratov State University.