OREANDA-NEWS  Scientists from the Moscow Institute of Physics and Technology and the Lopukhin Federal Scientific and Clinical Center for Physico-Chemical Medicine of the FMBA of Russia have developed a new import-independent method for analyzing biologically active substances, which will be useful for searching for anticoagulants - substances that prevent the formation of blood clots, the MIPT press service told RIA Novosti.

Anticoagulants are used for heart diseases, varicose veins and for the prevention of postoperative complications. Due to the high risk of thrombosis, some patients need constant use of anticoagulants. They can also cause undesirable effects for the body: allergic reactions, bleeding, abdominal pain, and others. Therefore, scientists continue to look for new, more effective and safe medicines.

For research, simple, cheap and, moreover, effective methods of biochemical analysis are needed, showing the effect of the substances under study on blood clotting. Scientists from the MIPT and the Lopukhin Federal Research and Scientific Research Center of the FMBA of Russia have proposed economically affordable methods of such analysis based on mass tests used in all clinical diagnostic laboratories.

"We have developed a technique for the biochemical analysis of substances exhibiting anticoagulation properties, which is based on clinical tests widely used to assess blood clotting in patients. All reagents and equipment necessary for analysis are of domestic production," said Valentin Manuvera, Associate Professor of the Department of Molecular and Translational Medicine at MIPT.

According to him, the developed technique makes it possible to detect anticoagulant substances in a variety of mixtures, as well as to conduct a primary analysis of their effect on blood clotting.