OREANDA-NEWS Scientists at Sechenov University are developing a dosage form based on gellan gum for intranasal drug delivery. This was reported to TASS by the press service of the university.

"They are creating a new dosage form (matrix) at the Institute of Pharmacy named after A. P. Nelyubin of Sechenov University. The matrix [is based on] gellan gum - a universal gel-forming agent," the report says.

Sechenovka believes that the developed dosage form is the most effective means for transporting drugs through the nasal cavity. The specialists found the optimal ratio of the substance in the intranasal delivery system and developed a laboratory model of the nasal cavity to find the best indicators of drug delivery.

Such a popular way of drug delivery, as through the nasal cavity, has a drawback - rapid removal from the nasal mucosa naturally due to fluctuations in the cilia.

"This problem is solved by smart systems that change from a liquid state to a gel-like one at the suction site. Due to the shape of the gel, the drug can stay longer on the nasal mucosa, which increases the efficiency of drug delivery, bypassing the blood-brain barrier," the press service reported.

The university noted that the developed matrix is safe and hypoallergenic. The authors of the study see a prospect in its use for the creation of intranasal vaccines. The created model of the nasal cavity can be used to test other drugs and systems, including those designed to deliver antitumor agents for glioblastoma therapy.